ART Guidelines
Table of Contents
How to use these guidelines
Abbreviations
MODULES
1. What’s new the 2023 guidelines update?
2. Nucleoside/nucleotide reverse transcriptase inhibitor class of antiretroviral drugs
3. Integrase strand transfer inhibitor class of antiretroviral drugs
4. Non-nucleoside reverse transcriptase inhibitor class of antiretroviral drugs
5. Protease inhibitor class of antiretroviral drugs
6. Initiation and timing of antiretroviral therapy
7. Baseline investigations
8. Viral load
9. CD4+ cell count
10. Resistance and genotyping
11. Initial antiretroviral therapy regimens for the previously untreated patient
12. Management of patients currently receiving first-line therapy
13. Management of patients starting or currently receiving second-line therapy
14. Third-line antiretroviral therapy
15. Laboratory monitoring of the efficacy and safety of antiretroviral therapy
16. Patients who return after stopping antiretroviral therapy
17. Drug-drug interactions
18. Tuberculosis
19. Pregnancy and breastfeeding
20. Liver disease
21. Renal disease
22. Psychiatric disease
23. Malaria
24. Antiretroviral drug-induced liver injury
25. Dyslipidaemia
26. Immune reconstitution inflammatory syndrome
27. Opportunistic infection prophylaxis
28. Adherence
References
References
![](/Images/Module 29.png)
Useful algorithms
Algorithm for initiation of antiretroviral therapy
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-71.jpg)
Summary of antiretrovirals and adverse effects
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Viral load monitoring
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-73.jpg)
CD4+ count monitoring
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-75.jpg)
Resistance tests
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-76.jpg)
Initiation of antiretroviral therapy in previously untreated patients
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-77.jpg)
Switching patients on non-nucleoside reverse transcriptase inhibitor-based first-line regimens to a dolutegravir-based regimen: Guided by viral load
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-74.jpg)
Protease inhibitor-based second-line regimens
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-79.jpg)
Third-line antiretroviral therapy regimens
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-80.jpg)
Monitoring of antiretroviral therapy
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-81.jpg)
Opportunistic infection prophylaxis
![](/Images/SAHCS Adult ART Guidelines A4 PDF Layout v2-82.jpg)