Page 203 - HIVMED_v21_i1.indb

Page 9 of 15 Original Research

A4 B4

110 50
100 40

90 30 +1.96 SD
34.1
i-STAT 48hr mol/I 80 (enzyma c 48hr - i-STAT 48hr) / Mean % 20 Mean
70
15.8
10
60
50 0 -1.96 SD
-2.8
40 –10
40 50 60 70 80 90 100 110 40 50 60 70 80 90 100 110
Enzyma c 48hr μmol/I Mean of enzyma c 48hr and i-STAT 48hr μmol/I
A5 B5
100 40
90 30 +1.96 SD
30.3
i-STAT 72hr mol/I 70 (enzyma c 72hr - i-STAT 72hr) / Mean % 10 0 Mean
20
80
12.3
60

50 –10 -1.96 SD

40 –20
40 50 60 70 80 90 100 40 50 60 70 80 90 100
Enzyma c 72hr μmol/I Mean of enzyma c 72hr and i-STAT 72hr μmol/I
A6 B6
100 60

90 50 +1.96 SD
43.3
40
i-STAT 96hr mol/I 70 (enzyma c 96hr - i-STAT 96hr) / Mean % 30 Mean
80
20
18.0
10
60
50 –10 0 -1.96 SD
-7.3
40 –20
40 50 60 70 80 90 100 50 60 70 80 90 100
Enzyma c 96hr μmol/I Mean of enzyma c 96hr and i-STAT 96hr μmol/I
FIGURE 4 (Continues...): Passing-Bablok regression curves (A) and Bland-Altman plots (B) comparing creatinine concentrations from the i-STAT device with those obtained
from the enzymatic method. Creatinine concentrations at (1) < 4 h, (2) 6 h, (3) 24 h, (4) 48 h, (5) 72 h and (6) 96 h.

The change in eGFR varied over time among the different equation: 25% eGFR at 48 h and 10% at 96 h compared to the
equations. The CG equation was the least sensitive to the baseline eGFR.
increase in serum creatinine: only 27% (n = 6/22) of eGFR-
based 96-h creatinine concentrations resulted in a change in Using the CKD-EPI equation as recommended by the
the Chronic Kidney Disease (CKD) stage when compared KDIGO guidelines, enzymatic and i-STAT renal
with baseline (i.e. the < 4-h eGFR; see Figure 5). The MDRD classification was noted at different time intervals with
v4 equation gave the greatest change in eGFR over 96 h: 50% changes between stages 1 and 2, which are not clinically
(n = 11/22) of participants at 24 h and 100% (n = 22/22) at 96 h significant for ARV drug choice. Using the kinetic Jaffe
showed an eGFR decline compared to baseline. The most method however, changes in the renal classification were
significant change of eGFR was noted with the MDRDv3 observed for 21 participants over the 96-h study period.

http://www.sajhivmed.org.za 195 Open Access