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elevated total cholesterol and triglyceride in this cohort will Acknowledgements
serve to further increase their cardiovascular risk.
Competing interests
Although not statistically significant, glycaemic control was The authors have declared that no competing interest exists.
poorer in the PLWHD compared to the PLWD with regards
to those:
Authors’ contributions
• with overall total thyroid disorders
• with SCH S.P. made substantial contributions to conception and design
• on ART of the work, writing of the paper and final approval and
agreed to be accountable for all aspects of the research. D.P.
and R.P. made substantial contributions to conception of the
Future prospective studies are needed to determine the
extent of this glycaemic difference between these groups of work, critically reviewed and edited the draft paper and final
patients which may aid in providing another therapeutic approval and agreed to be accountable for all aspects of the
avenue in improving overall diabetes control. research. D.S. made substantial contribution to the generation
of statistics and critically reviewed the article and agreed to
Strengths and limitations of study be accountable for all aspects of the research.
• Results of this study will help strengthen the case for Funding information
evaluation of thyroid disorders in PLWD but more
especially in PLWHD. This research received no specific grant from any funding
• The limitations of this study include that we only used a agency in the public, commercial or not-for-profit sectors.
single TSH level for diagnosis of thyroid dysfunction.
Assay-related analytic errors and transient thyroid Data availability statement
dysfunction secondary to drugs like lithium and Data sharing is not applicable to this article as no new data
amiodarone were not assessed. were created or analysed in this study.
• People living with HIV are at heightened risk of developing
the euthyroid sick syndrome. During periods of recovery
from acute illness, the TSH might be increased in this Disclaimer
condition and may result in an overdiagnosis of SCH. The views and opinions expressed in this article are those of
• Another limitation included that no T4 or T3 testing was the authors and do not necessarily reflect the official policy or
performed in patients with low or high TSH. As this was position of any affiliated agency of the authors.
a retrospective first visit study, we were able only to
collect TSH data that were gathered during screening on References
first visit.
• A further limitation remains that no viral load and 1. Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in
diabetic patients: Value of annual screening. Diabet Med. 1995;12(7):622–627.
effectiveness of ART data was available to assess if https://doi.org/10.1111/j.1464-5491.1995.tb00553.x
patients were taking their medication and whether ART 2. Shujing J, Chanqzhong J, Hoxtermann S, et al. Prevalence and influencing factors of
thyroid dysfunction in HIV-infected patients. BioMed Res Int. 2016;2016:3874257.
influenced the outcome. https://doi.org/10.1155/2016/3874257
3. Beltran S, Lescure FX, Deasilloud R, et al. Increased prevalence of hypothyroidism
Conclusion among human immunodeficiency virus-infected patients: A need for screening.
Clin Infect Dis. 2003;37(4):579–583. https://doi.org/10.1086/376626
4. Madeddu G, Spanu A, Chessa F, et al. Thyroid function in human immunodeficiency
Data on thyroid disorders in PLWHD are scarce. Our study virus patients treated with highly active antiretroviral therapy. Clin Endocrinol.
has shown an increased prevalence of thyroid disorders 2006;64(4):375–383. https://doi.org/10.1111/j.1365-2265.2006.02472.x
(most notably SCH) in HIV-uninfected PLWD and an even 5. Jain G, Devpura G, Gupta BS. Abnormalities in the thyroid function tests as
surrogate marker of advancing HIV infection in infected adults. JAPI. 2009;57(7):
higher prevalence in PLWHD. 508–510.
6. Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. Sage J
Thyroid Res. 2011;2011:439463. https://doi.org/10.4061/2011/439463
Young overweight women who are HIV infected and have 7. Stanicka S, Vondra K, Pelikanova T, Vlcek P, Hill M, Zamrazil V. Insulin sensitivity
DM seem to be particularly at risk of SCH. This is a ‘key’ and counter-regulatory hormones in hypothyroidism and during thyroid hormone
replacement therapy. Clin Chem Lab Med. 2005;43(7):715–720. https://doi.
population group that should be evaluated in all HIV clinics org/10.1515/CCLM.2005.121
for thyroid disorders. 8. Calza L, Manfredi R, Chiodo F, et al. Subclinical hypothyroidism in HIV-infected
patients receiving highly active antiretroviral therapy. J Acquir Immun Defic Syndr.
2002;31(3):361–363. https://doi.org/10.1097/00126334-200211010-00014
People living with human immunodeficiency virus and 9. Silva GA, Andrade MC, Sugui A, et al. Association between antiretrovirals and
diabetes on ART were shown to have an increased thyroid diseases: A cross-sectional study. Arch Endocrinol Metab. 2015;59(2):
116–122. https://doi.org/10.1590/2359-3997000000023
prevalence of thyroid dysfunction with poorer 10. Lambert M. Thyroid dysfunction in HIV infection. Baillieres Clin Endocrinol
lipaemic control. This particular group of patients on ART Metabol. 1994;8(4):825–835. https://doi.org/10.1016/S0950-351X(05)80303-9
need to be regularly screened for the aforementioned 11. Harslof M, Knudsen A, Benfield T, et al. No evidence of increased risk of thyroid
dysfunction in well-treated people living with HIV. AIDS. 2018;32(15):2195–2199.
cardiovascular complications. The introduction of combined https://doi.org/10.1097/QAD.0000000000001954
communicable–non-communicable disease clinics might 12. Madge S, Smith CJ, Lampe FC, et al. No association between HIV disease and
provide an integrated option for these patients. its treatment and thyroid function. HIV Med. 2007;8(1):22–27. https://doi.
org/10.1111/j.1468-1293.2007.00422.x
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