Page 204 - SAHCS HIVMed Journal Vol 20 No 1 2019

Page 8 of 10 Original Research

Appendix 1

TABLE 1-A1: Patients with positive urine Xpert rifampicin resistant results – details of additional tuberculosis tests and clinical course.
Study ID n Sample type Test Organism Susceptibility Susceptibility 12-week Classification of Heteroresistance Reason for classification
to rifampicin to isoniazid outcome urine Xpert
rifampicin
resistance†
KDHTB067 1 Blood Culture MTB - - Died Unknown No No samples could confirm
1 Blood Culture Neg - - resistance. Patient initially
improved on drug-sensitive TB
treatment and then experienced
rapid neurological deterioration
and died on day 3 of therapy.
KDHTB086 2 Blood Culture Neg - - Died True Resistance No Urine culture sample confirmed
1 CSF Culture Neg - - rifampicin resistance and sputum
Xpert indicated rifampicin
1 Sputm Xpert MTB Resistant - resistance.
1 Urine Culture MTB Resistant Resistant
KDHTB110 1 Blood Culture Neg - - Alive True Resistance No One blood and three urine culture
1 Blood Culture MTB Resistant Resistant samples confirmed rifampicin
resistance.
1 CSF Culture Neg - -
1 Sputum Culture Neg - -
3 Urine Culture MTB Resistant Resistant
KDHTB203 1 Blood Culture MTB - - Alive True Resistance Yes Sputum culture result showed
1 Blood Culture MTB Sensitive Sensitive rifampicin resistance and three
other cultures (sputum, blood
1 Sputum Culture MTB Sensitive - and urine) showed drug-sensitive
1 Sputum Culture MTB Resistant Sensitive MTB.
1 Urine Culture MTB Sensitive Sensitive
KDHTB238 1 Blood Culture MTB Resistant Sensitive LTFU True Resistance No Five cultures and one additional
4 Sputum Culture MTB Resistant Sensitive Xpert confirmed rifampicin
resistance.
1 Sputum Xpert MTB Resistant -
KDHTB242 1 Blood Culture Neg - - Alive True Resistance No Four cultures confirmed
1 Pleural Culture MTB Resistant Sensitive rifampicin resistance.
2 Sputum Culture MTB Resistant Sensitive
1 Urine Culture MTB Resistant Sensitive
KDHTB264 2 Blood Culture Neg - - Alive True Resistance No One culture result confirmed
1 CSF Culture Neg - - rifampicin resistance.
1 Pleural Culture MTB Resistant Resistant
2 Urine Culture Neg - -
KDHTB398 2 Blood Culture MTB Resistant Resistant Died True Resistance No Two culture results confirmed
1 CSF Culture Neg - - rifampicin resistance.
KDHTB416 1 Blood Culture Neg - - LTFU True Resistance No Two culture results confirmed
1 Sputum Culture Neg - - rifampicin resistance.
2 Sputum Culture MTB Resistant Resistant
KDHTB439 1 Blood Culture Neg - - Alive False Resistance No One culture and three Xpert
1 Pleural Xpert MTB Sensitive - results showed rifampicin
sensitivity.
1 Sputum Xpert MTB Sensitive -
1 Sputum Culture MTB Sensitive Sensitive
1 Urine Culture Contam - -
1 Urine Xpert MTB Sensitive -
KDHTB444 2 Blood Culture MTB - - Died True Resistance No One culture result confirmed
1 Blood Culture MTB Neg - rifampicin resistance.
1 Sputum Culture MTB Resistant Resistant
KDHTB445 1 Blood Culture Neg - - Alive True Resistance No Three culture results confirmed
3 Sputum Culture MTB Resistant Resistant rifampicin resistance.
KDHTB477 1 Blood Culture MTB Resistant Sensitive Alive True Resistance No Three culture results confirmed
2 Sputum Culture MTB Resistant Sensitive rifampicin resistance.
KDHTB479 1 Blood Culture Neg - - Alive False Resistance No Two culture results showed
2 Sputum Culture MTB Sensitive Sensitive rifampicin sensitivity.
KDHTB524 1 Blood Culture Neg - - Alive True Resistance No One culture and two Xpert results
1 Sputum Culture Neg - - confirmed rifampicin resistance.
2 Sputum Xpert MTB Resistant -
1 Sputum Culture MTB Resistant Sensitive
Table 1-A1 continues on the next page →

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