Page 205 - SAHCS HIVMed Journal Vol 20 No 1 2019

Page 9 of 10 Original Research

TABLE 1-A1 (Continues...): Patients with positive urine Xpert rifampicin resistant results – details of additional tuberculosis tests and clinical course.
Study ID n Sample type Test Organism Susceptibility Susceptibility 12-week Classification Heteroresistance Reason for classification
to rifampicin to isoniazid outcome of urine Xpert
rifampicin
resistance†
KDHTB531 1 Blood Culture MTB Sensitive Sensitive Died True Resistance Yes One culture result confirmed
1 Sputum Culture MTB Resistant Sensitive rifampicin resistance and one
showed rifampicin sensitivity.
KDHTB555 1 Blood Culture MTB Resistant Resistant Alive True Resistance No Three culture results confirmed
2 Blood Culture Neg - - rifampicin resistance.
2 Sputum Culture MTB Resistant Resistant
KDHTB556 1 Abscess Culture MTB Resistant Resistant Died True Resistance No Two culture results confirmed
1 Blood Culture Neg - - rifampicin resistance.
1 Sputum Culture MTB Resistant Resistant
KDHTB560 2 Blood Culture Neg - - Alive True Resistance No One culture result confirmed
1 Sputum Culture MTB Resistant Resistant rifampicin resistance.
KDHTB598 1 Blood Culture MTB Resistant Sensitive Died True Resistance No Three culture results confirmed
1 CSF Culture MTB Resistant Sensitive rifampicin resistance.
1 Sputum Culture MTB Resistant Sensitive
KDHTB616 1 Abscess Culture MTB Resistant Sensitive Alive True Resistance No Four culture results confirmed
2 Blood Culture MTB Resistant Sensitive rifampicin resistance.
5 Blood Culture Neg - -
1 Blood Culture MTB Resistant Sensitive
KDHTB627 1 Blood Culture MTB Resistant Sensitive Died True Resistance No One culture result confirmed
rifampicin resistance.
KDHTB631 1 Blood Culture Neg - - Alive True Resistance No One Xpert result and two culture
2 Sputum Culture MTB Resistant Resistant results confirmed rifampicin
resistance.
1 Sputum Xpert MTB Resistant -
1 Urine Culture Neg - -
KDHTB660 6 Blood Culture Neg - - Died True Resistance No Two culture results confirmed
2 Blood Culture MTB Resistant Sensitive rifampicin resistance.
KDHTB668 1 Blood Culture Neg - - Alive True Resistance No Treated for MDR-TB, improved
and survived.
JTBS021 1 Blood Culture Neg - - Alive Unknown No No samples confirmed rifampicin
1 Pleural eff Culture Neg - - resistance. Patient started
drug-sensitive TB treatment.
Inadequate information on
improvement or deterioration.
JTBS074 1 Urine Xpert Neg - - Alive False Resistance No No sample confirmed resistance
1 Blood Culture Neg - - and patient improved on
drug-sensitive TB treatment.
1 CSF Culture Neg - -
JTBS090 2 Urine Culture MTB Resistant Resistant LTFU True Resistance No Three culture results confirmed
rifampicin resistance.
1 Sputum Culture MTB Resistant Resistant
JTBS097† 2 Blood Culture MTB Sensitive Sensitive Died Contamination No Two culture results showed
1 Sputum Culture Neg - - rifampicin sensitivity. Patient
started drug-sensitive TB
1 Sputum Culture MTB Sensitive Sensitive treatment, then switched to
1 Urine Culture Neg - - MDR-TB treatment on basis of
urine Xpert result; however, died
1 Sputum Culture Contam - - before other drug susceptibility
1 CSF Culture Contam - - results were available.
JTBS098 1 Urine Xpert Neg - - Died True Resistance No No samples from enrolment
1 Blood Culture Neg - - admission confirmed rifampicin
resistance; however, a 7-month-
2 CSF Culture Neg - - old result showed rifampicin
1 Sputum Culture Contam - - resistance on pleural fluid, which
was untreated. It is unclear why
the patient was not treated for
MDR-TB and he died shortly after
admission to hospital.
JTBS099† 4 Tracheal Culture MTB Sensitive Resistant Alive Contamination No Four culture results showed
aspirate rifampicin sensitivity and patient
responded to drug-sensitive TB
treatment.
JTBS159 1 Urine Xpert Neg - - Alive False Resistance No No cultures confirmed rifampicin
1 Blood Culture Neg - - resistance and one sputum Xpert
showed rifampicin sensitivity.
2 Sputum Culture Neg - - Patient treated with drug-
1 Sputum Xpert MTB Sensitive - sensitive TB treatment and
improved.
1 Sputum Culture Contam - -
1 Urine Culture Neg - -
Table 1-A1 continues on the next page →

http://www.sajhivmed.org.za 198 Open Access