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useful resources
                  PMTCT FOR INFANTS 2019


                                                                                                                                  EMGuidance digital platform
                                                     First version April 2020

                                INFANT HIV PROPHYLAXIS AT BIRTH
            RISK                        MOTHER SCENARIO                               INFANT TREATMENT
        LOW RISK INFANT                                                                                                       EMGuidance (short for Essential Medical  Follow these  two steps to access the   green button to ‘downLoad seLected
      (BREASTFED OR EFF)   • Mother VL < 1000 c/mL at delivery                    NVP at birth and daily for 6 weeks          Guidance) is a mobile- and web-based  2019 guidelines:                     GuideLines’ will  appear on the
                                                                                          AZT for 6 weeks                     medi cines and treatment platform for                                      bottom of the screen.

                          • Mother not on ART at delivery, or                                    +
       HIGH RISK INFANT   • Mother on ART with HIV VL ≥ 1000 copies/mL at delivery,   NVP for a minimum of 12 weeks           medical professionals. We are pleased  1.  Sign up to access EMGuidance on
        AND BREASTFED      or prior 12 weeks                                   Infant  NVP  only  discontinued  after  confirmation   to announce that we have partnered   Google Play, the Apple App Store   For more information, read the following
                          • No HIV VL result available at delivery or prior 12 weeks   of maternal VL < 1 000 copies/mL and/or until 4   with the National Department of   or via Web:               articles applicable to your device:
                                                                               weeks after cessation of all breastfeeding     Health to launch the 2019 guidelines   •  Google Play: https://play.   •  Android:
                          • Mother not on ART at delivery, or
       HIGH RISK INFANT                                                                AZT + NVP for 6 weeks                  for antiretroviral therapy (ART) and the   google.com/store/apps/          https://intercom.help/essential-medical-
        AND EFF FROM      • Mother on ART with HIV VL ≥ 1000 copies/mL at  deliv-  Provided that avoiding breastfeeding is    prevention of mother-to-child transmission   details?id=emguidance.        guidance/en/articles/3529816-how-
                           ery, or prior 12 weeks
            BIRTH                                                                      documented and sustained                                                                                          to-download-the-latest-guidelines-on-the-
                          • No HIV VL result available at delivery or prior 12 weeks                                          of communicable infections (PMTCT) on     tompsa&hl=en_ZA
                                                                                                                              the EMGuidance platform.               •  App Store: https://              emguidance-platform-for-an-android-device
                          INFANT HIV PROPHYLAXIS AFTER DELIVERY                                                                                                         apps.apple.com/za/app/       •  iOS:
            RISK                        MOTHER SCENARIO                               INFANT TREATMENT                        About EMGuidance                          essential-medical-guidance/      https://intercom.help/essential-medical-
                                                                                                                                                                                                         guidance/en/articles/3529793-how-
                                                                                          AZT for 6 weeks                                                               id789625087                      to-download-the-latest-guidelines-on-the-
                                                                                                 +
       HIGH RISK INFANT   • Mother who tests HIV-positive during breastfeeding with   NVP for a minimum of 12 weeks           EMGuidance  offers  free access to     •  Web: http://emguidance.com       emguidance-platform-for-an-ios-device
                                                                                                                              comprehensive, up-to-date, locally
                            continued breastfeeding or has breastfed in the past
         DURING THE         week, regardless of infant’s age                   Infant  NVP  only  discontinued  after  confirmation   relevant, evidence-based  medicines  2.  Download the latest guidelines:
        BREASTFEEDING     • Breastfeeding mother with VL ≥ 1000 after previous    of maternal VL < 1 000 copies/mL            information and guidelines at the touch     Tap on the ‘Library’ icon on the home
            PERIOD          suppression on ART                                   If  the  mother  decides  to  stop  breastfeeding,                                                                    Should you  have any feedback
                                                                               prophylaxis  should  be  continued  for  4  weeks   of a button. The platform is accessible   screen. Select the ‘GuideLines’ tab,   or queries for our team regarding
                                                                               after cessation of all breastfeeding           via  your  desktop  or  smartphone.    followed by the ‘+’ icon.  Browse   these  guidelines or  use  of the
                          • Mother who tests positive after the baby is born and is                                           The platform is used by over 26 000    through  the  available  guidelines   platform, feel free to contact us at:
        UNDEFINED RISK                                                                   No ARV prophylaxis
                            not breastfeeding or stopped breastfeeding > 1 week ago                                           healthcare professionals across South   and select  the  relevant guidelines
                                                                                                                              Africa.  View this  video to see  how it   you want to download by checking   [email protected]
                                                INFANT TESTING                                PCR results must be             works: https://youtu.be/rGRefOK8-y4    the box next to the guideline title. A

                                                                                            checked within 7 days. If
      Mom HIV-positive during pregnancy or   •  PCR at birth                               positive, stop prophylaxis,
      diagnosed during labour                •  PCR at 10 weeks                                start ART and do
                                             •  PCR at 6 months                                confirmatory test
                                             •  Rapid test at 18 months
                                             •  Age-appropriate test* 6 weeks after stopping breastfeeding
      Mother who tests HIV-positive during   •  PCR immediately
      breastfeeding (continued or has breastfed  •  PCR at 10 weeks
      in the past week)                      •  PCR at 6 months
                                             •  Rapid test at 18 months
      Mother has VL > 1000 after previous    •  Age-appropriate test* 6 weeks after stopping NVP
      suppression on ART
                                             •  Age-appropriate test* 6 weeks after stopping breastfeeding
      Unknown status of mother; no continued   •  PCR and rapid test immediately:
      breastfeeding (includes orphans and aban-    PCR-positive: confirm with second PCR/VL
      doned babies)                                PCR-negative: repeat PCR at 10 weeks old or 4 weeks after stopping NVP
                                             •  PCR at 6 months
                                             •  Rapid Test at 18 months


                                  *AGE-APPROPRIATE TESTING IN INFANTS

                                   HIV
                    HIV
       AGE OF    SCREENING  CONFIRMATORY     • Test a symptomatic child any age
                                             • Any child under two years old with a positive HIV-PCR or a positive HIV rapid test should have
        CHILD       TEST          TEST         their HIV status confirmed with an HIV-PCR test on a new sample
                                             • At the clinician’s discretion, the HIV-PCR may be replaced by a viral load test, which has the
      < 18 months   PCR            PCR         advantage of both confirming the HIV diagnosis and providing a baseline VL for monitoring the
      18 months -                              child’s response to ART                                                        Free instant access to     Medicines                  Medicines                  Interaction checker
        2 years     Rapid          PCR       • Any child who tests HIV-positive should initiate ART according to the Paediatric ART guideline   locally relevant medicines,   South Africa’s most   Each medicine has a   Improve the safety and
                                               as a matter of urgency
       > 2 years    Rapid         Rapid      • Do not wait for the confirmatory result before initiating ART but ensure result is checked   info and clinical guidelines.  comprehensive, evidence-  detailed monograph.  effectiveness of prescribed
                                                                                                                                                         based medicines resource.                             medicines.
       HIV Nursing Matters | October 2020 | page 30            Based on the Guideline for the Prevention of Mother to Child Transmission of                                                    HIV Nursing Matters | October 2020 | page 31
                                                                           Communicable Infections . National
                                                                  Department of Health, South Africa. 2019, updated March 2020.
         This publication was supported under funding provided by the Global Fund to Fight AIDS, Tuberculosis and Malaria through the National Department of Health of South Africa and the
         NDoH Pharmacovigilance Centre for Public Health Programmes. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Global
                                            Fund or the National Department of Health of South Africa
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