Page 318 - SAHCS HIVMed Journal Vol 20 No 1 2019

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wrote the initial draft of the manuscript. C.F. assisted in 9. Bishburg E, Eng RH, Smith SM, Kapila R. Yield of bone marrow culture in the
diagnosis of infectious diseases in patients with acquired immunodeficiency
conceptualising the study and writing the protocol, syndrome. J Clin Microbiol. 1986;24(2):312–314.
supervised the study, assisted in the data interpretation, and 10. Quesada AE, Tholpady A, Wanger A, Nguyen AN, Chen L. Utility of bone marrow
assisted in writing and finalising the manuscript. examination for workup of fever of unknown origin in HIV patients. J Clin Pathol.
2015;68(3):241–245. https://doi.org/10.1136/jclinpath-2014-202715
11. Riley UB, Crawford S, Barrett SP, Abdalla SH. Detection of mycobacteria in bone
marrow biopsy specimens taken to investigate pyrexia of unknown origin. J Clin
Funding Pathol. 1995;48(8):706–709. https://doi.org/10.1136/jcp.48.8.706
12. Lin SH, Lai CC, Huang SH, Hung CC. Hsueh PR. Mycobacterial bone marrow
This research received no specific grant from any funding infections at a medical centre in Taiwan, 2001–2009. Epidemiol Infect.
agency in the public, commercial or not-for-profit sectors. 2014;142(7):1524–1532. https://doi.org/10.1017/S0950268813002707
13. Keiser P, Rademacher S, Smith JW. Utility of bone marrow culture and biopsy in
the diagnosis of disseminated infections in AIDS. Am J Hematol. 1997;56(1):1–4.
https://doi.org/10.1002/(SICI)1096-8652(199709)56:1<1::AID-AJH1>3.0.CO;2-U.
Data availability statement 14. Northfelt DW, Mayer A, Kaplan LD, et al. The usefulness of diagnostic bone
marrow examination in patients with human immunodeficiency virus (HIV)
Data sharing is not applicable to this article as no new data infection. J Acquir Immune Defic Syndr. 1991;4(7):659–666.
were created or analysed in this study. 15. Shisana O, Rehle T, Simbayi LC, et al. South African national HIV prevalence,
incidence and behaviour survey, 2012. Cape Town: HSRC Press; 2014.
16. National Health Laboratory Service. GeneXpert MTB/RIF progress report [homepage
Disclaimer on the Internet]. 2015 [cited 2019 Feb 10]. Available from: https://www.nhls.ac.za/
assets/files/GeneXpert%20Progress%20Report%20February%202015%20 Final.pdf.
The views expressed in the article are those of the authors 17. Gauteng Province Department of Health. Charlotte Maxeke Academic Hospital.
[cited 2017 Jun 18]. Available from: https://www.health.gpg.gov.za/hospitals/
and not an official position of the institution or funder. pages/Charlotte-Maxeke-Academic.aspx.
18. UNAIDS. Global AIDS Update 2016. Joint United Nations Programme on HIV/AIDS.
References 2016 [cited 2017 Jun 18]. Available from: https://www.unaids.org/sites/default/
files/media_asset/global-AIDS-update-2016_en.pdf.
19. Holmes CB, Wood R, Badri M, et al. CD4 decline and incidence of opportunistic
1. Statistics South Africa. Mid-year population estimates 2016: Statistical release infections in Cape Town, South Africa: Implications for prophylaxis and treatment.
P0302 [homepage on the Internet]. 2016 [cited 2017 Jun 18]. Available from: J Acquir Immune Defic Syndr. 2006;42(4):464–469. https://doi.org/10.1097/01.
http://www.statssa.gov.za/publications/P0302/P03022015.pdf. qai.0000225729.79610.b7
2. Drain PK, Losina E, Parker G, et al. Risk factors for late-stage HIV disease 20. Simelela NP, Venter WDF. History of HIV in SA: A brief history of South Africa’s
presentation at initial HIV diagnosis in Durban, South Africa. PLoS One. response to AIDS. S Afr Med J. 2014;104(3):249–251. https://doi.org/10.7196/
2013;8(1):e55305. https://doi.org/10.1371/journal.pone.0055305 SAMJ.7700
3. Karstaedt AS, Pantanowitz L, Omar T, Sonnendecker HEM, Patel M. The utility of 21. Pande A, Bhattacharyya M, Pain S, Ghosh A, Samanta A. Diagnostic yield of bone
bone-marrow examination in HIV-infected adults in South Africa. QJM. marrow examination in HIV associated FUO in ART naive patients. J Infect Public
2001;94(2):101–105. https://doi.org/10.1093/qjmed/94.2.101 Health. 2010;3(3):124–129. https://doi.org/10.1016/j.jiph.2010.07.006
4. Van Schalkwyk WA, Opie J, Novitzky N. The diagnostic utility of bone marrow 22. World Health Organization. Global tuberculosis report 2014 (WHO/HTM/
biopsies performed for the investigation of fever and/or cytopenias in HIV-infected TB/2014.08). Geneva: WHO; 2014.
adults at Groote Schuur Hospital, Western Cape, South Africa. Int J Lab Hematol. 23. Steingart KR, Schiller I, Horne DJ et al. Xpert1 MTB/RIF assay for pulmonary
2011;33(3):258–266. https://doi.org/10.1111/j.1751-553X.2010.01280.x tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev.
5. Brook M, Ayles H, Harrison C, Rowntree C, Miller R. Diagnostic utility of bone 2014;2014 Jan(1):CD009593. https://doi.org/10.1002/14651858.CD009593.pub3
marrow sampling in HIV positive patients. Genitourin Med. 1997;73(2):117–121. 24. Lawn SD, Kerkhoff AD, Pahlana P, Vogt M, Wood R. Diagnostic yield of tuberculosis
https://doi.org/10.1136/sti.73.2.117 using sputum induction in HIV-positive patients before antiretroviral therapy. Int J
6. Luther JM, Lakey DL, Larson RS, et al. Utility of bone marrow biopsy for rapid Tuberc Lung Dis. 2012;16(10):1354–1357. https://doi.org/10.5588/ijtld.12.0174
diagnosis of febrile illnesses in patients with human immunodeficiency virus 25. Lawn SD, Gupta-Wright A. Detection of lipoarabinomannan (LAM) in urine is
infection. South Med J. 2000;93(7):692–697. https://doi.org/10.1097/00007611- indicative of disseminated TB with renal involvement in patients living with HIV
2000070 00-00011 and advanced immunodeficiency: Evidence and implications. Trans R Soc Trop
7. Tanaka PY, Hadad DJ, Barletti SC, De Souza SA, Calore EE. Bone marrow biopsy in Med Hyg. 2015;110(3):180–185. https://doi.org/10.1093/trstmh/trw008
the diagnoses of infectious and non-infectious causes in patients with advanced 26. Chosmata BI. Comparison of multiple methods of diagnosis of mycobacterial
HIV infection. J Infect. 2007;54(4):362–366. https://doi.org/10.1016/j.jinf.2006. infection from bone marrow samples of HIV positive patients [doctoral
06.007 dissertation]. Johannesburg: Faculty of Health Sciences, University of the
8. Engels E, Marks PW, Kazanjian P. Usefulness of bone marrow examination in the Witwatersrand; 2011.
evaluation of unexplained fevers in patients infected with human 27. Sedick Q, Vaughan J, Pheeha T, Alli NA. Bone marrow aspirate microscopy versus
immunodeficiency virus. Clin Infect Dis. 1995;21(2):427–428. https://doi.org/ bone marrow trephine biopsy for detection of Mycobacterial tuberculosis infection.
10. 1093/clinids/21.2.427 S Afr Med J. 2015;105(9):773–775. https://doi.org/10.7196/SAMJnew.8171

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