Page 426 - HIVMED_v21_i1.indb

Page 7 of 8 Original Research

from paediatric to adult HIV programmes – are needed to 9. Nglazi MD, Kranzer K, Holele P, et al. Treatment outcomes in HIV-infected
counter older adolescents dropping out of care. Female adolescents attending a community-based antiretroviral therapy clinic in South
Africa. BMC Infect Dis. 2012;12:21. https://doi.org/10.1186/1471-2334-12-21
adolescents who initiate ART whilst pregnant should receive 10. Nachega JB, Hislop M, Nguyen H, Dowdy DW, Chaisson RE, Regensberg L.
special attention. This aligns with the increased need to Antiretroviral therapy adherence, virologic and immunological outcomes in
adolescents compared with adults in southern Africa. J Acquir Immune Defic
provide and integrate appropriate sexual reproductive health Syndr. 2009;51(1):65–71. https://doi.org/10.1097/QAI.0b013e318199072e
services to ALWH. Behavioural interventions to improve 11. Kariminia A, Law M, Davies M, et al. Mortality and losses to follow-up among
adolescents living with HIV in the IeDEA global cohort collaboration. JIAS.
adherence and RiC should ideally be embedded in 2018;21:e25215. https://doi.org/10.1002/jia2.25215
community health services so that this forms part of an 12. Western Cape Government Health. 2016. The Western Cape consolidated
guidelines for HIV treatment: Prevention of mother-to-child transmission of
‘extended’ HIV treatment package. HIV (PMTCT), children, adolescents and adults. Western Cape: Western Cape
Government Health.
Acknowledgements 13. Western Cape Government Health: HAST. June 2017 ART data sign-off document.
Western Cape: Western Cape Government Health; 2017.
Competing interests 14. Osler M, Hilderbrand K, Hennessey C, et al. A three-tier framework for monitoring
antiretroviral therapy in high HIV burden settings. JIAS. 2014;17:18908. https://
doi.org/10.7448/IAS.17.1.18908
The authors have declared that no competing interests exist. 15. Lilian RR, Rees K, McIntyre JA, Struthers HE, Peters RPH. Same-day antiretroviral
therapy initiation for HIV-infected adults in South Africa: Analysis of routine
data. PLoS One. 2020;15(1):e0227572. https://doi.org/10.1371/journal.pone.
Authors’ contributions 0227572
16. Western Cape Government Health. Update to antiretroviral guidelines: Circular
E.K. conducted the research under the supervision of B.v.W., H116 of 2012 [homepage on the Internet]. 2012 [cited 2017 Oct 06]. Available
from: http://www.doh.gov.za.
and F.M. and B.v.W. drafted the first manuscript. E.K. and 17. Nabukeera-Barungi N, Elyanu P, Asire B, et al. Adherence to antiretroviral therapy
F.M. commented on all drafts. All authors approved the final and retention in care for adolescents living with HIV from 10 districts in Uganda.
version. BMC Infect Dis. 2015;15:520. https://doi.org/10.1186/s12879-015-1265-5
18. Zanoni BC, Archary M, Buchan S, et al. Systematic review and meta-analysis of the
adolescent HIV continuum of care in South Africa: The Cresting Wave. BMJ Global
Health. 2016;1:e000004. https://doi.org/10.1136/bmjgh-2015-000004
Funding information 19. Adejumo OA, Malee KM, Ryscavage P, Hunter SJ, Taiwo BO. Contemporary issues
on the epidemiology and antiretroviral adherence of HIV-infected adolescents in
This project was supported under a Medical Research sub-Saharan Africa: A narrative review. J Int AIDS Soc. 2015;18(1):20049. https://
Council of South Africa Self-Initiated Research grant. doi.org/10.7448/IAS.18.1.20049
20. Matyanga CMJ, Takarinda KC, Owiti P, et al. Outcomes of antiretroviral therapy
among younger versus older adolescents and adults in an urban clinic,
Data availability statement Zimbabwe. Public Health Action. 2016;6(2):97–104. https://doi.org/10.5588/
pha.15.0077
21. Kranzer K, Bradley J, Musaazi J, et al. Loss to follow-up among children and
Data are available upon request to the author. adolescents growing up with HIV infection: Age really matters. J Int AIDS Soc.
2017;20(1):21737. https://doi.org/10.7448/IAS.20.1.21737
Disclaimer 22. Okoboi S, Ssali L, Yansaneh A, et al. Factors associated with long-term antiretroviral
therapy attrition among adolescents in rural Uganda: A retrospective study. J Int
AIDS Soc. 2016;19(554):20841. https://doi.org/10.7448/IAS.19.5.20841
The views and opinions expressed in this article are those of 23. Dahourou DL, Gautier-Lafaye C, Teasdale CA, et al. Transition from paediatric to
the authors and do not necessarily reflect the official policy or adult care of adolescents living with HIV in sub-Saharan Africa: Challenges, youth-
friendly models, and outcomes. J Int AIDS Soc. 2017;20(Suppl. 3):21528. https://
position of the South African Medical Research Council or doi.org/10.7448/IAS.20.4.21528
University of the Western Cape. 24. Cervia JS. Easing the transition of HIV infected adolescents to adult care.
AIDS Patient Care STDS. 2013;27(12):692–696. https://doi.org/10.1089/apc.
2013.0253
References 25. Pinzón-Iregui MC, Ibanez G, Beck-Sagué C, Halpern M, Mendoza RM. ‘… like
because you are grownup, you do not need help’: Experiences of transition from
pediatric to adult care among youth with perinatal HIV infection, their caregivers,
1. UNICEF. Turning the tide against AIDS will require more concentrated focus on and health care providers in the Dominican Republic. J Int Assoc Provid AIDS Care.
adolescents and young people [homepage on the Internet]. 2019 [cited 2019 Oct 21]. 2017;16(6):579–587. https://doi.org/10.1177/2325957417729749
Available from: https://data.unicef.org/topic/hivaids/adolescents-young-people/
26. Vijayan T, Benin AL, Wagner K, et al. We never thought this would happen:
2. Joint United Nations Programme on HIV/AIDS (UNAIDS). Data [homepage on the Transitioning care of adolescents with perinatally acquired HIV infection from
Internet]. 2018 [cited 2019 Oct 21]. Available from: https://www.unaids.org/ paediatrics to internal medicine. AIDS Care. 2009;21(10):1222–1229. https://doi.
sites/default/files/media_asset/unaids-data-2018_en.pdf org/10.1080/09540120902730054
3. South African National HIV prevalence, incidence, behaviour and communication 27. Jones C, Ritchwood TD, Taggart T. Barriers and facilitators to the successful
survey [homepage on the Internet]. 2017 [cited 2019 Dec 03]. Available from: transition of adolescents living with HIV from pediatric to adult care in
http://www.hsrc.ac.za/uploads/pageContent/9234/SABSSMV_Impact_ low and middle-income countries: A systematic review and policy
Assessment_Summary_ZA_ADS_cleared_PDFA4.pdf analysis. AIDS Behav. 2019;23(9):2498–2513. https://doi.org/10.1007/
4. Maskew M, Bor J, MacLeod W, Carmona S, Sherman GG, Fox MP. Adolescent s10461-019-02621-6
HHIV treatment in South Africa’s national HIV programme: A retrospective cohort 28. Kung TH, Wallace ML, Snyder KL, et al. South African healthcare provider
study. Lancet HIV. 2019;6(11):e760–e768. https://doi.org/10.1016/S2352- perspectives on transitioning adolescents into adult HIV care. SAMJ.
3018(19)30234-6 2016;106(8):804–808. https://doi.org/10.7196/SAMJ.2016.v106i8.10496
5. UNICEF. Children and AIDS [homepage on the Internet]. 2017 [cited 2018 Aug 18]. 29. Nuwagaba-Biribonwoha H, Kiragga AN, Yiannoutsos CT, et al. Adolescent
Available from: https://data.unicef.org/wp-content/uploads/2017/11/HIVAIDS- pregnancy at antiretroviral therapy (ART) initiation: A critical barrier to retention
Statistical-Update-2017.pdf on ART. J Int AIDS Soc. 2018;21:e25178. https://doi.org/10.1002/jia2.25178
6. UNAIDS. 90-90-90: An ambitious treatment target to help end the AIDS epidemic 30. Knettel BA, Cichowitz C, Ngocho JS, et al. Retention in HIV care during pregnancy
[homepage on the Internet]. UNAIDS; 2014 [cited 2019 Oct 15]. Available from: and the postpartum period in the option B+ era: A systematic review and meta-
http://www.unaids.org/sites/default/files/media_asset/90-90-90_en.pdf analysis of studies in Africa. J Acquir Immune Defic Syndr. 2018;77(5):427–438.
7. Mugglin C, Haas AD, Van Oosterhout JJ, et al. Long-term retention on antiretroviral https://doi.org/10.1097/QAI.000000000001616
therapy among infants, children, adolescents and adults in Malawi-term retention 31. Ssali L, Kalibala S, Birungi J, et al. Retention of adolescents living with HIV in care,
on antiretroviral therapy among infants, children, adolescents and adults in treatment, and support programs in Uganda. 2014; Washington, DC: United
Malawi: A cohort study. PLoS One. 2019;14(11):e0224837. https://doi.org/10.1371/ States Agency for International Development. Available from: https://www.
journal.pone.0224837 popcouncil.org/uploads/pdfs/2014HIVCore_UgandaAdolHAART.pdf.
8. Wong VJ, Murray KR, Phelps BR, Vermund SH, McCarraher DR. Adolescents, young 32. Ridgeway K, Dulli LS, Murray KR, et al. Interventions to improve antiretroviral
people, and the 90-90-90 goals: A call to improve HIV testing and linkage to therapy adherence among adolescents in low- and middle-income countries:
treatment. AIDS. 2019;31(Suppl. 3):S191–S194. https://doi.org/10.1097/QAD. A systematic review of the literature. PLoS One. 2018;13(1):e0189770. https://
0000000000001539 doi.org/10.1371/journal.pone.0189770
http://www.sajhivmed.org.za 418 Open Access