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Page 2 of 7  Original Research


              to  seek confirmatory  testing by a  trained  healthcare   Methods
              professional.  Furthermore, the independence of HIVST
                        12
              presents considerable challenges surrounding the monitoring   Study design
              and  evaluation  (M&E)  of  HIVST  programmes,  which  are   This evaluation was a cross-sectional pilot study that ran for
              required by public health stakeholders to understand the   four weeks in July 2018.  A convenience sample of 300
              uptake and effectiveness. 13                          consenting adults was recruited from inner-city Johannesburg,
                                                                    South Africa. Recruitment was based around the Hillbrow
              Strong mobile phone penetration in low- and middle-income   Health Clinic by trained healthcare workers (HCW) who
              countries (LMIC) 14,15  has led to the development of a variety   went into the surrounding communities and spoke to the
              of  mobile  health  (mHealth)  interventions  to  complement   public about the current study. Those interested were
              HIVST.  These  include  telephone  hotlines,  short  message   screened against inclusion/exclusion criteria, then brought
              service interventions, internet-based platforms and mobile   to the Hillbrow Clinic to provide consent and complete the
              applications (apps). 16,17,18,19,20  A Brazilian study conducted in   study. Participants were included if they owned a mobile
              2019  showed  that  an  internet-based  intervention  targeting   phone (feature phones, or higher, for app compatibility) and
              men who have sex with men led to 21.4% of online      could provide a valid mobile phone number, were 18 years or
              participants self-reporting, whilst an interactive voice   older, able to read English and able to provide written
              response telephone line in South Africa was found to link   informed consent. Participants were excluded if they did not
                                     21
              9.8% of participants to care.  Whilst these platforms have   meet the inclusion criteria, were currently on a pre-exposure
              shown  varied  success,  the  introduction  of  mHealth   prophylaxis (PrEP) regime or any HIV treatment medication,
              interventions for linkage to care and M&E are in line with the   could not provide valid identification or had any condition
              South  African National Department of Health mHealth   that may have interfered with the testing process (such as
              Strategy (2015), and should be explored further. 22   intoxication or poor vision).
                                                                                               TM
              Despite data concerns in LMICs,  recent trends are    Development of the Aspect  HIV-self-testing
                                            23
              towards the development of downloadable apps due to   mobile app
              their  agility  and  scalability.   The app  interface  also   The Aspect  HIVST app was designed for  Android and
                                       24
                                                                             TM
              provides developers with a malleable platform that can be   deployed by SystemOne, LLC (Northampton, MA, USA),
              tailored to individual users, allowing them to curate a   a  diagnostic connectivity and disease intelligence company.
              collection of HIVST information, resources and guidance   The Aspect  HIVST app was designed to be integrated with
                                                                            TM
              for testers, whilst also capturing the HIVST result data. 19,20    the existing Aspect  software platform, a system designed to
                                                                                  TM
              Recently, HIVSmart , a Canadian app, was developed to   integrate directly with diagnostic instruments in order to collect
                              TM
              guide users through the testing process, link them to care,   digital results for real-time monitoring and reporting via an
              and store the HIVST result data. Preliminary evaluations   operational dashboard. The Aspect  API can also communicate
                                                                                              TM
              in key Canadian populations, as well as healthcare workers   with RedCap, an existing South African healthcare database,
              in  South  Africa  have  shown  the  app  to  be  feasible  and   and this application is already being used for reporting HIV
              acceptable; however, neither HIVSmart , nor any other   viral load results and early infant HIV diagnosis (EID).
                                               TM
              app, has been developed or tested for the general
              population in LMICs. 9,20,25                          The Aspect  HIVST app was developed using Dimagi
                                                                             TM
                                                                    Commcare (Washington, USA), a common data-gathering
              South Africa has shown previous acceptance of HIV-related   platform. The app was structured to allow the self-tester to
              mHealth interventions with SmartLink, an app that improved   collect their own demographic information,  provide the
              linkage to care for clinic-based HIV testing in participants   tester with instructions on how to perform self-testing, input
              under 30 years of age.   Another successful mHealth   their interpretation of the test result, and capture a photo of
                                   26
              intervention, MomConnect, has been used by over 2 million   the HIVST strip (Figure 1). Demographic data were collected
              pregnant South African women with information regarding   with one question per page and included the self-tester’s age,
              their pregnancy, whilst also creating a national pregnancy
              registry. 27,28

              The Aspect  HIVST app was developed to help strengthen
                       TM
              and complement HIVST  programmes by supporting self-
              testers through testing, facilitating linkage to care and
              digitising  the  reporting  of  HIVST  results  through  an
              operational dashboard for M&E. The specific objective of this
              pilot study was to evaluate the acceptability and feasibility of
                      TM
              the Aspect  HIVST app for individuals from the inner city of
              Johannesburg, in order to advise further scale-up. We present
              the findings from this pilot.                         FIGURE 1: Screenshots of the Aspect  HIV-self-testing mobile app. 29
                                                                                          TM
                                           http://www.sajhivmed.org.za 181  Open Access
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