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Page 6 of 9  Original Research


              Figure 3 shows the summary of the change in the number   reported fewer partners and 59 (19%) had more partners
              of  sexual partners and engagement in concurrent sexual   (Figure  3).  For  concurrency  (past  3  months),  at  baseline,
              partnerships at the 3-month follow-up visit (relative to   111 (31% of n = 353 with available data) reported engaging in
              baseline). Amongst the 368 men who attended the follow-up   one or more concurrent sexual partnerships. By 3 months
              visit at 3 months, 57 (15%) did not provide information on the   post-VMMC,  58 (52% of 111) had  ended the  concurrent
              number of partners during the past 1 month at either baseline   partnership. In contrast, amongst the 242 (69%) who did not
              and/or follow-up. Data on engagement in concurrent sexual   report any concurrent sexual partnerships at baseline,
              partnerships were available for 353 (96%) of the 368 men who   47  (19% of 242) had initiated a concurrent partnership at
              attended follow-up.                                   3 months (Figure 3). After adjustment for possible selection
                                                                    bias because of loss to follow-up at 3 months, we found no
              At baseline, the mean (95% CI) number of sexual partners   evidence of sexual risk compensation following VMMC:
              (past 1 month) was 1.60 (1.48, 1.65). Although the majority   mean change in number of partners was -0.04 (95% CI: -0.15,
              (59% of n = 311 with available data) of men reported the same   0.08; p = 0.61) and the proportion engaging in concurrency
              number of partners at 3 months post-VMMC,  70 (23%)   was 0.04 (95% CI: -0.05, 0.14; p = 0.38).

                                                                    Tables 2 and 3 present the results of post-hoc analyses aimed
                  250                               248             at identifying predictors of any engagement (irrespective of
                                                                    change from baseline or pre-circumcision) in high-risk sexual
                Number of par vipants  150  182                     behaviour at 3 months post-VMMC. In multivariable-
                  200
                                                                    adjusted models (simultaneously adjusted for potential
                                                                    selection bias because of loss to follow-up), alcohol
                                                                    consumption (Table 2; risk ratio [RR]: 1.72; 95% CI: 1.19, 2.49)
                  100
                  50
                                                                    positively associated with reporting two or more partners
                         17  52    41  12        58     47          and transactional sex (RR: 1.77; 95% CI: 1.13, 2.77) were
                      1                   6                         (past 1 month) at follow-up. Alcohol consumption was also
                   0                                                positively associated with concurrency at 3 months post-
                    9 Fewer  2 Fewer  1 Fewer No changes  1 more  2  more  3  more  Ended No change  Ini tated  VMMC (Table 3; RR: 2.30; 95% CI: 1.45, 3.66). In contrast,


                       Number of partners  Concurrent partnerships,  older age at first sexual intercourse (21 years and older) was
                                                                    negatively associated with multiple sexual partners (Table 2;
                        past one month      past three months
                                                                    RR: 0.50; 95% CI: 0.30, 0.84) at follow-up. No other attitudinal
              FIGURE 3: Summary of change in the number of sexual partners (past 1 month)   or behavioural covariates were significantly associated
              and  engagement  in  concurrent  partnerships  at  3  months  amongst  men   with either outcome in either univariable- or multivariable-
              undergoing  voluntary  medical  male  circumcision  in  Gaborone,  Botswana,
              2012–2015.                                            adjusted analyses.
              TABLE 2: Univariable- and multivariable-adjusted attitudinal and behavioural predictors of multiple sexual partners (past 1 month) at 3 months amongst men undergoing
              voluntary medical male circumcision in Gaborone, Botswana, 2012–2015.
              Attitudinal and behavioural predictors          Univariable-adjusted†          Multivariable-adjusted†,‡
                                                         RR       95% CI       p         RR       95% CI      p
              Reasons for circumcision
              Personal hygiene                            1         ref.       -         1         ref.       -
              HIV protection                             0.96     0.68–1.35   0.80      0.99     0.70–1.40   0.96
              Other                                      0.90     0.60–1.35   0.61      0.86     0.58–1.28   0.45
              Knowledge of HIV risk
              Correct knowledge: VMMC partially reduces HIV risk for men  1.12  0.71–1.77  0.62  1.15  0.73–1.83  0.54
              Correct knowledge: VMMC does not impact HIV risk for women  1.14  0.73–1.78  0.55  1.13  0.71–1.80  0.60
              Risk compensation scale§
              Condom use is not necessary if the man is circumcised  1.02  0.86–1.21  0.80  1.04  0.86–1.25  0.69
              If I am circumcised, sex is safe without a condom  0.99  0.85–1.17  0.95  0.97     0.82–1.14   0.70
              Being circumcised means a man can worry less about HIV  1.03  0.92–1.14  0.63  1.05  0.94–1.17  0.36
              If a man is circumcised, he can have more sexual partners  1.10  0.87–1.39  0.42  1.08  0.86–1.37  0.49
              Alcohol consumption                        1.80     1.23–2.62  0.002      1.80     1.23–2.62   0.004
              Age at first sexual intercourse (years)
              < 18                                        1         ref.       -         1         ref.       -
              18–20                                      0.98     0.72–1.34   0.92      0.92     0.68–124    0.59
              ≥ 21                                       0.51     0.30–0.85   0.01      0.50     0.30–0.84   0.01
              Exchanged money for sex, past 12 months    1.64     1.07–2.52   0.02      1.77     1.13–2.77   0.01
              RR, risk ratio; CI, confidence intervals; HIV, human immunodeficiency virus; VMMC, voluntary medical male circumcision.
              †, Estimated from a weighted modified Poisson regression model with weights constructed to adjust for selection bias because of loss to follow-up.
              ‡, Estimated from a weighted modified Poisson regression model with weights constructed to adjust for selection bias because of loss to follow-up and confounding because of the following
              baseline covariates: age, relationship status, religious affiliation, education, employment and household use of woods as cooking fuel.
              §, Responses based on Likert scale (range 0–5 with 0 and 5 denoting ‘strongly disagree’ and ‘strongly agree’, respectively).

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