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       dependence, and a core element of harm  facing people with opioid dependence.  range of psychosocial interventions        References
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                                                                                                                                   Substances: When science was left behind. Geneva: Global
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                                                                                                                                                                       Developing an advocacy agenda for increasing access to opioid
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                                                                                                                                                                       who use drugs in South Africa. 2018;108(10):800–802.
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       Most OST is provided by civil society                                  drug-related stigma, and the challenges              2010;1(7515):3–14.               25.   Bateman C. The drug-addicted doctor - Who dares to care?   40.   Marks M. Opioid substitution therapy. Ment Heal Matters.
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       organisations and academic institutions,  Other harm reduction         of our times, contribute to the high levels        9.   UNODC. World Drug Report 2019. Executive Summary.   26.   Hughes CE, Stevens  a. What Can We Learn From The   41.   Belackova V, Salmon A. Overview of International Literature.
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       mostly funded by international donors,  interventions                  of harms related to drug use. Changes              10.   Scheibe A, Shelly S, Versfeld A, Howell S, Marks M. Safe   Portuguese Decriminalization of Illicit Drugs? Br J Criminol. 2010   Sydney: United Medically Supervised Injecting Centre; 2017.
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       maintenance.  Prescription by private  lives of people who use drugs and their  approaches that can have immediate        12.   Dada S, Harker-Burnhams N, Erasmus J, Lucas W, Parry C,   28.   Marlatt GA. Harm reduction: Come as you are. Addict Behav   2018;108(2):182–186.
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       practitioners also takes place, but rarely  communities. Safe consumption sites, or  effect. Harm reduction is an option that   Bhana A, et al. SACENDU. Monitoring alcohol, tobaccoe and   29.   World Health Organization. Consolidated Guidelines on HIV
                                                                                                                                   other drug use trends (South Africa): July – December 2018. Vol.
       in the context of a structured programme.   injecting sites,  are spaces for the safe and  is ethical and evidence-based. Harm   Phase 45. Cape Town: MRC; 2018.   Prevention, Diagnosis, Treatment and Care for Key Populations.
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                                           hygienic use of drugs. Safe consumptions  reduction is more than giving people who    13.   UNODC. World Drug Report 2019 data. World Drug Report   30.   Wilson DP, Donald B, Shattock AJ, Wilson D, Fraser-Hurt
                                                                                                                                   2019. Vienna; 2019. https://wdr.unodc.org/wdr2019/index.
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       There are only single (but different)  sites significantly reduce the risk of death  inject drugs clean injecting equipment,   14.   UNAIDS. Do No Harm. Health, human rights and people who   N. The cost-effectiveness of harm reduction. Int J Drug
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       suppliers of methadone and bupre-   from overdose and increase uptake  or increasing access to OST for people               use drugs. Report. Geneva: UNAIDS; 2016. http://search.  31.   UNODC, INPUD, UNAIDS, UNFPA, WHO, USAID, et al.
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       norphine in South Africa. The lack of  of  substance use treatment  services.    with an opioid dependency. It is a shift in   17&lang=tr&site=ehost-live       Implementing Comprehensive HIV and HCV Programmes with
                                                                                                                                                                       People Who Inject Drugs. Practical guidance for collaborative
       competition has led to unethically high  Community distribution of naloxone  philosophy that recognises the complexity    15.   Haysom S. Hiding in plain sight. Heroin’ s stealthy takeover of   inteventions. (IDUIT). Vienna: UNODC; 2017. p. 1–175.
                                                                                                                                   South Africa. Policy Brief. Pretoria: ENACT; 2019.
       prices of these medications. Methadone  to manage overdoses among people  of life, and prioritises the needs of people,
       in South Africa costs ten times more than  who use opioids is another important,  and supports them on their journey to
       in other middle-income settings. [37]  Single  effective service that saves lives.  A  reach their goals. Most importantly, harm
                                                                       [31]
       supply also poses a risk to supply chain                               reduction saves lives.
       management. A methadone stockout
       took place in November 2019. The threat
       of the stockout resulted in anxiety for over
       1 000 people on OST across the country   A few recommendations to consider
       and distrust of the health service. The
       largest OST service in Johannesburg ran   1.  Reflect on your views around drugs and people who use them
       out of methadone for 2 weeks, with almost   2.  Avoid judging people and use non-stigmatising language when speaking
       all of their 36 clients (several of whom   about, or with, people who use drugs
       were on antiretroviral therapy) at that time   3.  Empower yourself with accurate information about drugs and treatment.

       reverting back to injecting drugs.        Read and use the Southern African HIV Clinicians Society’s Harm
                                 [38]
                                                 Reduction Guidelines due for release in the last quarter of 2020
       During South Africa’s response to the   4.  Explore ways to provide access to sterile injecting equipment for people
       COVID-19 pandemic, large temporary        who inject drugs and provide mechanisms for safe disposal in your
       shelters  were  established  for homeless   practice
       people. For people with opioid depend-  5.  Demand increased access to OST
       ence, a break in access to heroin triggered   6.  Advocate for the decriminalisation of drug use and policy that supports
       withdrawal and the likely loss of tolerance   human rights and evidence-based public health interventions relating to
       to opioids – increasing risk of overdose   drug use.
                                      [39]
       should opioids be used at a later stage.
       Several municipalities recognised the risk
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