Page 211 - SAHCS HIVMed Journal Vol 20 No 1 2019
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Page 5 of 6 Original Research
There was no difference in in-hospital mortality between Thus, in addition to AIDS-defining illnesses, clinicians must
HIV-positive and HIV-negative surgical inpatients. This have a high index of suspicion for squamous cell carcinoma
contrasts with a study in Malawi, which, in a small cohort, and oesophageal, anal, penile cancers in HIV-positive
found a higher mortality rate in HIV-positive patients. 17 patients. In countries experiencing a high prevalence of HIV,
surgical training programmes and surgical units in hospitals
In several studies from SSA, most of them in the pre-ART era, must anticipate the types of surgeries that HIV-positive
a significant difference in surgical outcomes and complications patients are likely to require, such as excision of malignancies,
20
was not found. However, there seems to be evidence for a and provide adequate training, staffing and facilities to meet
higher mortality rate in HIV-positive patients undergoing the needs for the future.
emergency surgery. 21
Acknowledgements
HIV and malignancies Competing interests
In addition to the known AIDS-defining malignancies, HIV- The authors declare that there were no conflicts of interest
infected patients are also more likely to suffer from certain during the writing of this article.
5
cancers. In our study, there was a strong correlation between
HIV and certain malignancies. In the adult age group 15–49
years, 46.3% of the patients with proven malignancies were Authors’ contributions
HIV-positive. Unsurprisingly, HIV prevalence was highest P.M. performed data collection, data analysis and
among cervical cancer patients (63.2%). In addition to this, interpretation, wrote the article and acted as the corresponding
however, we found a higher prevalence (51.4%) in the author. M.S. supervised development of the article and
squamous cell carcinoma group and a 2.54-fold greater helped in data interpretation and manuscript evaluation. P.T.
likelihood of having HIV. Oesophageal, skin and penile conceived of the presented idea and helped in manuscript
cancers were also common in HIV-positive patients. The evaluation. P.M. and P.T. designed the study and developed
association with HPV and penile cancer is well established. the methodology.
22
While ART has decreased the incidence of NHL, more cases
of oesophageal cancer and stomach cancer are being References
diagnosed. Whether this is also because of HPV or an
independent risk factor, such as is the case for lung cancer, 1. Bowa K, Kawimbe B, Mugala D, et al. A review of HIV and surgery in Africa. Open
AIDS J. 2016;10:16–23. https://doi.org/10.2174/1874613601610010016
remains unclear. This may be because HIV-positive patients 2. Haac BE, Charles AG, Matoga M, et al. HIV testing and epidemiology in a hospital-
23
encounter healthcare workers more often through accessing based surgical cohort in Malawi. World J Surg. 2013;37:2122–2128. https://doi.
org/10.1007/s00268-013-2096-4
ART and may therefore have a lower threshold for seeking 3. Wang CJ, Silverberg MJ, Abrams DI. Non-AIDS-defining malignancies in the HIV-
help at a health facility, leading to better diagnosis of disease. infected population. Curr Infect Dis Rep. 2014;16:406. https://doi.org/10.1007/
s11908-014-0406-0
4. Mitsuyasu RT. Non-AIDS-defining cancers. Top Antivir Med. 2014;22:660–665.
Within our cohort, few men undergoing surgery for prostate
cancer were HIV-positive and the average age of the group 5. UNAIDS. 2015. HIV and AIDS estimates. Geneva: UNAIDS.
6. Zimbabwe Ministry of Health. GARPR Zimbabwe country progress report 2016.
with prostate cancer was 71.2 years. Thus, the average age of Harare: Ministry of Health Zimbabwe; 2016.
HIV-positive patients with malignancies was significantly 7. Cacala SR, Mafana E, Thomson SR, Smith A. Prevalence of HIV status and CD4
younger than that of HIV-negative patients with malignancies. counts in a surgical cohort: Their relationship to clinical outcome. Ann R Coll Surg
Engl. 2006;88:46–51. https://doi.org/10.1308/003588406X83050
8. Zimbabwe National Statistics Agency (ZIMSTAT), ICF International. Zimbabwe
Our study had several limitations. Outpatients, and therefore demographic and health survey 2010–2011. Harare: ZIMSTAT and ICF International
Inc.; 2012.
most cases of surgery and maternity cases, were excluded. 9. Zimbabwe National Statistics Agency (ZIMSTAT), ICF International. Zimbabwe
Older men were overrepresented. Likewise, not all histology demographic and health survey 2015. MD, USA: ZIMSTAT and ICF International
Inc.; 2016.
results were available. Also, because of the lack of access to 10. Martinson NA, Omar T, Gray GE, et al. High rates of HIV in surgical patients in
routine laboratory investigations, no biochemical profile was Soweto, South Africa: Impact on resource utilisation and recommendations for
available for the patients. Furthermore, information about HIV testing. Trans R Soc Trop Med Hyg. 2007;101:176–182. https://doi.
org/10.1016/j.trstmh.2006.04.002
hepatitis, TB or HPV coinfections was not available in most 11. World Health Organization. Guidance on provider-initiated HIV testing and
of the cases. Because this was a retrospective chart review, counselling in health facilities. Switzerland: World Health Organization; 2007.
only inpatient mortality could be captured. In this setting of 12. Pope DS, Deluca AN, Kali P, et al. A cluster-randomized trial of provider-initiated
(opt-out) HIV counseling and testing of tuberculosis patients in South Africa.
rural Zimbabwe, it would be very difficult to follow-up J Acquir Immune Defic Syndr. 1999;48:190–195. https://doi.org/10.1097/QAI.
v0b013e3181775926
patients to determine 30-day mortality. 13. Weigel R, Kamthunzi P, Mwansambo C, Phiri S, Kazembe PN. Effect of provider-
initiated testing and counselling and integration of ART services on access to
HIV diagnosis and treatment for children in Lilongwe, Malawi: A pre- post
In conclusion, this study shows a higher HIV prevalence comparison. BMC Pediatr. 2009;9:80. https://doi.org/10.1097/QAI.0b013e3181
among adult surgical inpatients than in the general 775926
population. We demonstrated that testing and treatment is 14. Kiene SM, Bateganya M, Wanyenze R, Lule H, Nantaba H, Stein MD. Initial
outcomes of provider-initiated routine HIV testing and counseling during
well established in this specific rural Zimbabwean hospital. outpatient care at a rural Ugandan hospital: Risky sexual behavior, partner HIV
testing, disclosure, and HIV care seeking. AIDS Patient Care STDS. 2010;24:
Interestingly, in-hospital mortality was not higher in HIV- 117–126. https://doi.org/10.1089/apc.2009.0269
positive patients compared to HIV-negative patients. There 15. Zimbabwe Ministry of Health and Child Welfare. Guidelines for implementation
of provider-initiated HIV testing and counselling. Harare: Zimbabwe Ministry of
were correlations between HIV and certain malignancies. Health; 2014.
http://www.sajhivmed.org.za 204 Open Access