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Page 7 of 8  Guideline


              organ transplants involving HIV-positive patients should be   2.  South African national HIV prevalence, incidence, behaviour and communication
                                                                      survey  [homepage  on  the  Internet].  2017  [cited  2020  Jan  20].  Available  from:
              subject to formal ethics review by a local HREC. Rigorous   http://www.hsrc.ac.za/en/media-briefs/hiv-aids-stis-and-tb/sabssm-launch-
              patient protections are particularly vital in the case of HIV-  2018v2
              negative recipients, given the ethical considerations involved.   3.  Choi AI, Shlipak MG, Hunt PW, Martin JN, Deeks SG. HIV-infected persons continue
                                                                      to  lose  kidney  function  despite  successful  antiretroviral  therapy.  AIDS.
                                                                      2009;23(16):2143–2149. https://doi.org/10.1097/QAD.0b013e3283313c91
              We recommend involvement of the local HREC as early as
                                                                    4.  Rasch MG, Helleberg M, Feldt-Rasmussen B, et al. Increased risk of dialysis and
              possible in the process, to allow adequate time for discussions   end-stage  renal  disease  among  HIV  patients  in  Denmark  compared  with  the
                                                                      background population. Nephrol Dial Transplant. 2014;29(6):1232–1238. https://
              and detailed interactions.                              doi.org/10.1093/ndt/gft289
                                                                    5.  Rasch MG, Engsig FN, Feldt-Rasmussen B, et al. Renal function and incidence of
                                                                      chronic kidney disease in HIV patients: A Danish cohort study. Scand J Infect Dis.
              Furthermore, we strongly recommend that all data concerning   2012;44(9):689–696. https://doi.org/10.3109/00365548.2012.673730
              transplantations with HIV-positive donors or recipients   6.  Pineda  JA,  Garcia-Garcia  JA,  Aguilar-Guisado  M,  et  al.  Clinical  progression  of
              should be peer-reviewed, published and distributed      hepatitis C virus-related chronic liver disease in human immunodeficiency virus-
                                                                      infected  patients  undergoing  highly  active  antiretroviral  therapy.  Hepatology.
              timeously because the experiences shared from other centres   2007;46(3):622–630. https://doi.org/10.1002/hep.21757
              may have biomedical and ethical implications.         7.  Thio CL, Seaberg EC, Skolasky R, Jr., et al. HIV-1, hepatitis B virus, and risk of liver-
                                                                      related  mortality  in  the  multicenter  cohort  study  (MACS).  Lancet.
                                                                      2002;360(9349):1921–1926. https://doi.org/10.1016/S0140-6736(02)11913-1
              Conclusion                                            8.  Soriano V, Puoti M, Garcia-Gasco P, et al. Antiretroviral drugs and liver injury. AIDS.
                                                                      2008;22(1):1–13. https://doi.org/10.1097/QAD.0b013e3282f0e2fd
                                                                    9.  Kaspar MB, Sterling RK. Mechanisms of liver disease in patients infected with HIV.
              These guidelines aim to sketch an evidence-based framework   BMJ  Open  Gastroenterol.  2017;4(1):e000166.  http://doi.org/10.1136/bmjgast-
              for HIV-positive donors and recipients regarding solid organ   2017-000166
                                                                    10. Naicker S, Rahmanian S, Kopp JB. HIV and chronic kidney disease. Clin Nephrol
              transplantation. It is expected that specific recommendations   [serial online]. 2015 [cited 2006 Mar 29]; 83(7 Suppl 1):32–38. Available from:
                                                                      https://doi.org/10.5414/CNP83S032
              will need to be adjusted as further evidence becomes available.
                                                                    11. Organ Donor Foundation. Statistics [homepage on the Internet]. No date [cited
              Furthermore, individual patient circumstances may require   2019 Oct 13] Available from: https://www.odf.org.za/info-and-faq-s/statistics.html
              deviations from this document, provided that such departures   12. Fabian J, Crymble K. End-of-life care and organ donation in South Africa – It’s time
                                                                      for national policy to lead the way. S Afr Med J. 2017;107(7):11947. https://doi.
              have the backing of the local research ethics committee and   org/10.7196/SAMJ.2017.v107i7.12486
              contribute to continuing research in the field. These guidelines   13. Tzakis AG, Cooper MH, Dummer JS, Ragni M, Ward JW, Starzl TE. Transplantation
                                                                      in HIV+ patients. Transplantation. 1990;49(2):354–358.
              aim to provide support and a framework for the expansion of   14. Poli F, Scalamogna M, Pizzi C, Mozzi F, Sirchia G. HIV infection in cadaveric renal
              programmes incorporating HIV-positive donors and recipients.  allograft  recipients  in  the  North  Italy  transplant  program.  Transplantation.
                                                                      1989;47(4):724–725. https://doi.org/10.1097/00007890-198904000-00031
                                                                    15. Dummer JS, Erb S, Breinig MK, et al. Infection with human immunodeficiency virus
              Acknowledgements                                        in the Pittsburgh transplant population. A study of 583 donors and 1043 recipients,
                                                                      1981–1986. Transplantation. 1989;47(1):134–140.
              Competing interests                                   16. Stock PG, Barin B, Murphy B, et al. Outcomes of kidney transplantation in HIV-
                                                                      infected  recipients.  N  Engl  J  Med.  2010;363(21):2004–2014.  https://doi.
                                                                      org/10.1056/NEJMoa1001197
              The authors have declared that no competing interests exist.
                                                                    17. Muller  E,  Kahn  D,  Mendelson  M.  Renal  transplantation  between  HIV-positive
                                                                      donors  and  recipients.  N  Engl  J  Med.  2010;362(24):2336–2337.  https://doi.
                                                                      org/10.1056/NEJMc0900837
              Authors’ contributions                                18. Muller  E,  Barday  Z,  Mendelson  M,  Kahn  D.  HIV-positive-to-HIV-positive  kidney
                                                                      transplantation – Results at 3 to 5 years. N Engl J Med. 2015;372(7):613–620.
              All authors contributed equally to this work.           https://doi.org/10.1056/NEJMoa1408896
                                                                    19.  National Institutes of Health. Final human immunodeficiency virus (HIV) organ policy
                                                                      equity  (HOPE)  act  safeguards  and  research  criteria  for  transplantation  of  organs
              Funding information                                     infected with HIV [homepage on the Internet]. 2015. p. 73785–73796. Available from:
                                                                      https://regulations.justia.com/regulations/fedreg/2015/11/25/ 2015-30172.html
              This  research  received  no  specific  grant from any  funding   20. HIV.gov. Kidney transplant from living HIV-positive donor to HIV-positive recipient:
                                                                      What does this mean? [homepage on the Internet]. 2019 [cited 2019 Dec 10].
              agency in the public, commercial or not-for-profit sectors.  Available  from:  https://www.hiv.gov/blog/kidney-transplant-living-hiv-positive-
                                                                      donor-hiv-positive-recipient-what-does-mean
                                                                    21. UNOS.org.  100  people  transplanted  thanks  to  HOPE  Act  [homepage  on  the
              Data availability statement                             Internet]. 2018 [cited 2019 Oct 13]. Available from: https://unos.org/news/100-
                                                                      people-transplanted-thanks-to-hope-act/
              Data sharing is not applicable to this article as no new data   22. Lippincott CK. IDCM CME issue 1–10: Solid-organ transplants and HIV: A 30 year
              were created or analysed in this study.                 journey [homepage on the Internet]. 2019 [cited 2020 Jan 05]. Available from:
                                                                      https://main.ccghe.net/content/idcm-issue-1-10-solid-organ-transplants-and-
                                                                      hiv-30-year-journey
                                                                    23. Koval CE, Farr M, Krisl J, et al. Heart or lung transplant outcomes in HIV-infected
              Disclaimer                                              recipients.  J  Heart  Lung  Transplant.  2019;38(12):1296–1305.  https://doi.
                                                                      org/10.1016/j.healun.2019.09.011
              Specific recommendations provided here are intended only   24. Morabito  V,  Grossi  P,  Lombardini  L,  et  al.  Solid  organ  transplantation  in  HIV+
              as a guide to clinical management, based on expert consensus   recipients: Italian experience. Transplant Proc. 2016;48(2):424–430. https://doi.
                                                                      org/10.1016/j.transproceed.2015.12.049
              and best current evidence. Treatment decisions for patients   25. Aguero F, Castel MA, Cocchi S, et al. An update on heart transplantation in human
              should be made by their responsible clinicians, with due   immunodeficiency  virus-infected  patients.  Am  J  Transplant.  2016;16(1):21–28.
                                                                      https://doi.org/10.1111/ajt.13496
              consideration for individual circumstances. The most current   26. Kern RM, Seethamraju H, Blanc PD, et al. The feasibility of lung transplantation in
              version of this document should always be consulted.    HIV-seropositive patients. Ann Am Thorac Soc. 2014;11(6):882–889. https://doi.
                                                                      org/10.1513/AnnalsATS.201402-083OC
              References                                            27. Botha J, Conradie F, Etheredge H, et al. Living donor liver transplant from an HIV-
                                                                      positive mother to her HIV-negative child: Opening up new therapeutic options.
                                                                      AIDS. 2018;32(16):F13–F9. https://doi.org/10.1097/QAD.0000000000002000
              1.  UNAIDS.  Country  factsheets  –  South  Africa  [homepage  on  the  Internet].  2017   28. Canaud G, Dejucq-Rainsford N, Avettand-Fenoel V, et al. The kidney as a reservoir
                [cited 2020 Jan 20]. Available from: http://www.unaids.org/en/regionscountries/  for  HIV-1  after  renal  transplantation.  J  Am  Soc  Nephrol.  2014;25(2):407–419.
                countries/southafrica                                 https://doi.org/10.1681/ASN.2013050564


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