Medicines Information Centre
7th Edition
National Department of Health
Fifth Edition 2024
National Department of Health
A Clinical Guideline for the Diagnosis and Treatment of Drug-susceptible TB in Children and Adolescents in South Africa
National Department of Health
Consistently and correctly taking treatment and fostering combination prevention services
May 2024. Version 1.
Based on Clinical Management of Rifampicin-Resistance Tuberculosis: Updated Clinical Reference Guide, September 2023 and Circular 2/23: Implementation of BPaL-L regimen, South African National Department of Health
National Department of Health
For the management of protease inhibitor (PI) and dolutegravir (DTG) resistance
National Department of Health
National Clinical Management Training.
Participant Manual
National Department of Health
Updated clinical reference guide
National Department of Health
The programme that was formally known as Prevention of Mother-to-Child Transmission of Transmissible Infections, is from now onwards called the Vertical Transmission Prevention (VTP) programme.
This guideline will be a component of the Maternity Care guidelines and the National Consolidated ART guidelines.
National Department of Health
Fifth edition 2023
National Department of Health
Minimum differentiated models of care package to support linkage to care, adherence and retention in care
National Department of Health
Clinical Guidelines for the Management of HIV in Adults, Pregnancy and Breastfeeding, Adolescents, Children, Infants and Neonates
(June 2023, Version 3)
National Department of Health
(April 2023)
National Department of Health
Minimum differentiated models of care package to support linkage to care, adherence and retention in care.
Adherence Guidelines for HIV, TB and NCDs (Updated April 2023)
National Department of Health
The purpose is to guide implementation, the management of patients started on TPT and the monitoring and evaluation requirements. It is intended for clinicians,
pharmacists and healthcare managers in the public and private sector.
NDoH
Standard Operating Procedures - Minimum package of interventions to support linkage to care, adherence and retention in care
National Department of Health
Updated clinical reference guide
Compiled by the Child and Adolescent Committee of the Southern African HIV Clinicians Society in collaboration with the Department of Health
National Department of Health
Guidelines developed to improve the management of viral hepatitis in South Africa
National Department of Health
The purpose of this document is to outline the process and procedure for quality TB screening and early identification of patients who require TB testing to minimize avoidable delays in diagnosis and treatment thus reducing TB transmission.
National Department of Health
3rd edition, March 2022
National Department of Health
March 2022
National Department of Health
Nov 2021
National Department of Health
October 2021
National Department of Health
Information for healthcare workers
National Department of Health
Reference: 2021/06/29/EDP/01
National Department of Health
Policy update: February 2021
National Department of Health
Primary Healthcare Level
2020 Edition
National Department of Health
Updated pricing – circular version 3
for children who have not started or are more than 1 month behind
Compiled by Child and Adolescent Committee of SA HIV Clinicians Society in collaboration with the Department of Health
2020
National Department of Health
Updated March 2020
National Department of Health
Updated March 2020
National Department of Health
March 2020
National Department of Health
July 2020
National Department of Health
These guidelines were developed with the purpose to:
• inform healthcare workers in the public and private sectors about the disease, its epidemiology in South Africa and current methods of diagnosis and therapy
• strengthen the healthcare response to viral hepatitis
• empower communicable diseases workers and stakeholders to make informed decisions regarding
appropriate and cost effective interventions
National Department of Health
PPE – what to wear during COVID pandemic
National Department of Health
Clean and disinfect patient areas
National Department of Health
Keep your workstation clean
National Department of Health
How to travel safely using public or staff transport
National Department of Health
Protect yourself and others
National Department of Health
The aim of the SOPs is to enable delivery of effective differentiated care to patients within the health care system.
National Department of Health
Reference 2020/05/13/EDP/01
National Department of Health
Version 4
National Department of Health
To align with the EML decision, the PMTCT guideline includes the update that nevirapine (NVP) is no longer recommended as part of a triple-therapy ART regimen, and specifically in pregnant women living with HIV. NVP will still be used as a stat dose with TLD for women in labour but not yet on ART.
National Department of Health
• The CD4 count threshold for TPT eligibility in pregnancy has been amended from 100 cells/µL to 350 cells/µL. This is aligned with EML and PMTCT Guideline (changes to page 7).
• All clients with a positive CrAg test should be referred for a lumbar puncture. This is aligned with EML (changes to pages 4 and 6).
• Removal of resistance testing for adults and adolescents failing a first-line DTG-based regimen. This is based on an assessment of current resources (changes to page 17).
National Department of Health
A1 poster
National Department of Health
Z-fold flyer
National Department of Health
USE OF CLOTH FACE-MASKS BY MEMBERS OF THE GENERAL PUBLIC IN SOUTH AFRICA DURING THE COVID-19 PANDEMIC
National Department of Health
Document prepared by the Occupational Health and Safety Committee – Covid-19 Response.
This is an interim guide that may be updated as the outbreak in South Africa intensifies, to guide additional workforce preserving strategies.
National Department of Health
Version 1
National Department of Health
Updated March 2020
National Department of Health
Version 3
National Department of Health
March 2020
National Department of Health
The 2019 Consolidated Guidelines have been revised to include a new formulation of the fixed dose combination (FDC) of tenofovir (TDF) 300 mg + lamivudine (3TC) 300 mg + dolutegravir (DTG) 50 mg (TLD) for all eligible adults, adolescents and children 10 years and older and weighing 35 kg or more. These guidelines have further simplified ART provision and harmonized PMTCT and the management of children, adolescents and adults with HIV/AIDS, TB and other common opportunistic infections.
National Department of Health
Circular No 01 of 2020
National Department of Health
2019
National Department of Health
A Clinical Reference Guide
National Department of Health
Nov 2019
National Department of Health
Published October 2019
Department of Health
Adapted from: Standard Treatment Guidelines and Essential Medicine List PHC
National Department of Health
Adapted from Standard Treatment Guidelines and EML PHC
National Department of Health
Recommendations
National Department of Health
MULTI-DRUG RESISTANT TUBERCULOSIS
Department of Health
Recommendations about the use of the HIV medicine DOLUTEGRAVIR in Pregnancy in response to the Potential Risk of Birth Defects
Department of Health
Third line algorithm for children over 3 years
Department of Health
Paed third line dosing chart
Department of Health
Application for third line antiretrovirals
National Department of Health
Booklet
National Department of Health
2018
National Department of Health
Listeriosis: Clinical recommendations for diagnosis and treatment
National Department of Health
Please find attached the application form that is required to be completed for access to Third Line Antiretroviral Therapy. Please complete the form using the following steps:
• Download: Please download the PDF document.
• Open: Open the PDF document using Adobe Reader. Ensure you have the latest version of the form may not work properly.
• Fill: This is an editable PDF, and the minimum required fields will be highlighted. Please click on each field and enter the required patient information.
Please do not print out the document to complete by hand.
• Save: Once you have completed the document please save it to your computer by clicking the icon on the top left of the screen. Save it using the patient name and surname as a unique identifier.
• Submit: Close Adobe and attach the completed and renamed application form to an email and submit it to the following email address: [email protected]
Department of Health
This Adolescent and Youth Health Policy aims to promote the health and well-being of young people, aged 10-24 years.
Prepared by the National Department of Health
National Department of Health
July 2016
The 2016 "Guidelines for Expanding Combination Prevention and Treatment Options for Sex Workers: Oral Pre-Exposure Prophylaxis (PrEP) and Test and Treat (T&T)" have been released by the SA National Department of Health.
This document, and the associated circular (FDC ARV Circular, dated 25.05.2015) provides guidance on how to prescribe FDCs. This reduces the need to use single-agent lamivudine tablets.
The PHC Standard Treatment Guidelines EML should be used at clinics, community health centres and gateway clinics for the management of conditions commonly presenting at this level.
The DoH requires that all third line drugs should be appropriately motivated for, using the form provided.
April 2015 guidelines for the prevention of mother-to-child transmission of HIV (PMTCT) and the management of HIV in children, adolescents and adults
There are four fixed-dose ARV combinations available. Here are the NDoH guidelines for their use in first and second-line ART regimens.
Sexually Transmitted Infections: NDOH Management Guidelines 2015
Additional Content to the National Sexually Transmitted Infections Care and Treatment Course for Health Care Workers
Includes STI guideline changes, national STI services results reporting and high transmission areas: key populations
National consolidated guidelines for the prevention of mother-to-child transmission of HIV (PMTCT) and the management of HIV in children, adolescents and adults
NDOH circular on changes in the prescription of progestin subdermal implants (implanon) in women taking enzyme-inducing drugs such as efavirenz, rifampicin and certain epilepsy medicines.
Notice to public health facilities of a supplier shortage of NVP 100ml and 240ml
The latest National Tuberculosis Management Guidelines - 2014
Implementing all these strategies in combination will not only reduce the burden of disease in
children but help us attain the goal of zero TB deaths in children. Partnerships with communities
and more research into new diagnostic tests, better vaccines and child friendly medicine
formulations will provide immense opportunities for attaining this goal.
Circular issued by the National Department of Health stating that ALL eligible patient groups should be offered to switch to the fixed-dose combination of Tenofovir(TDF) + Emtricitabine (FTC)+ Efavirenz (EFV).
NDoH First Line Comprehensive Management and Control of Sexually Transmitted Infections
National Strategic Plan for HIV Prevention, Care and Treatment for Sex Workers First Edition 2013
NDOH protocol for accessing third-line antiretroviral therapy in the public sector
NDOH motivation form for third line ART
Algorithm for HIV-exposed and infected children, from HCT into care
Newly revised protocol for the management of health complaints in the public sector
NDOH algorithm for the management of HIV-exposed children
These are the latest complete ART guidelines from the National Department of Health. Official implementation date is the 1st of April 2013.
This document is a PDF version of the National Department of Health's Overview presentation of the latest ART guidelines, to be implemented from April 1st 2013. This includes the introduction of fixed dose combination regimens.
This document, published by the South African National Department of Health on 13 March 2013, contains several demonstrative case studies for trainers to teach the correct implementation of Fixed Dose Combination (FDC) regimens in terms of the latest guidelines. It includes several realistic case studies and the accompanying answers.
This document contains the short combined guidelines for antiretroviral treatment for South Africa in 2013. This document was published on 14 March 2013 by the National Department of Health. This includes standardised national guidelines for adults and adolescents, children, HIV-positive pregnant women as well as HIV-positive newborn infants.
This document, published by the South African National Department of Health on 13 March 2013, includes the departments standardised guidelines for implementation of Fixed Dose Combination (FDC) regimens. Thus its purpose is to update frontline clinical staff for the implementation of FDC guidelines in PMTCT, paediatric and adult ARV treatment.
These presentation slides, put together by the South African National Department of Health, should aid in training staff for the correct implementation of the 2013 standardised guidelines for Fixed Dose Combination (FDC) antiretroviral therapy regimens.
World Health Organization
The WHO Global tuberculosis report 2024 provides a comprehensive and up-to-date assessment of the TB epidemic and of progress in prevention, diagnosis and treatment of the disease, at global, regional and country levels.
World Health Organization
WHO’s updated guidelines prioritize broader access to PEP, including
community-based delivery and task sharing to mitigate barriers such as stigma and to ensure timely access
post exposure.
World Health Organization
These consolidated guidelines on differentiated HIV testing services (HTS) bring together existing and new guidance on testing across different settings and populations.
World Health Organization
Action for access in low- and middle-income countries
World Health Organization
The objective of the 2024 guidelines is to provide updated evidence-informed recommendations on key priority topics.
World Health Organization
Brief report 2024
World Health Organization
Normative guidance
World Health Organization
WHO
World Health Organization
WHO
World Health Organization
Recommendations for a public health approach
World Health Organization
WHO recommends that long-acting injectable cabotegravir (CAB-LA) may be offered as an additional HIV prevention option for people at substantial risk of HIV infection. CAB-LA is an injectable form of pre-exposure prophylaxis (PrEP) that has been shown to be highly effective at reducing the risk of HIV acquisition.
World Health Organization
MODULE 4: Treatment: tuberculosis care and support
World Health Organization
MODULE 4: treatment: tuberculosis care and support
World Health Organization
The objective of these guidelines is to provide updated, evidence-informed recommendations for treating adults, adolescents and children living with HIV who have cryptococcal disease.
World Health Organization
WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents
World Health Organization
Technical report
World Health Organization
Each year, the WHO Global TB Report provides a comprehensive and up-to-date assessment of the TB epidemic, and of progress in prevention, diagnosis and treatment of the disease, at global, regional and country levels. This is done in the context of global TB commitments, strategies and targets.
The 2020 WHO global TB report showcases the progress made towards ending the TB epidemic, and puts in stark perspective the current and potential impact of the COVID-19 pandemic, in
eroding the hard-won gains of recent years.
Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection
Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection
AN OVERVIEW OF VALIDATION STRUCTURES AND RESPONSIBILITIES
AT NATIONAL, REGIONAL AND GLOBAL LEVELS
Module 4: Treatment - Drug-Resistant Tuberculosis treatment
Module 4: Treatment - Drug-Resistant Tuberculosis treatment
These guidelines aim to provide recommendations for the diagnosis, treatment, and management of disseminated histoplasmosis in persons living with HIV
DRIVING IMPACT THROUGH PROGRAMME MONITORING AND
MANAGEMENT
Module 1: prevention: tuberculosis preventive treatment
Module 1: prevention: tuberculosis preventive treatment
World Health Organization
This policy brief highlights new guidance to optimize HIVST implementation, including effective service delivery models, linkage to care and support tools.
WHO
WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic, and of progress in prevention, diagnosis and treatment of the disease, at global, regional and country levels.
The 2019 updated guidelines provide the latest recommendations.
This guideline examines the evidence and makes recommendations and remarks on the implementation of some of the details of breastfeeding counselling, such as frequency, timing, mode and provider of breastfeeding counselling, to improve breastfeeding practices. The objective of this guideline is to provide global, evidence-informed recommendations on breastfeeding counselling, as a public health intervention, to improve breastfeeding practices among pregnant women and mothers who intend to breastfeed, or are currently breastfeeding, and their infants and children.
World Health Organization
A WHO guide for planners, implementers and managers
These guidelines aim to provide evidence-based recommendations on the care and treatment of persons diagnosed with chronic hepatitis C infection.
World Health Organization
Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection
These new guidelines supersede previous WHO policy documents on the management of LTBI in people living with HIV, household contacts of people with active TB, other groups at risk of developing TB, and for LTBI testing. The consolidated guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management, adapted to the national and local epidemiology of TB, the availability of resources, the health infrastructure and other national and local determinants. The guidelines are to be used primarily in national TB and HIV control programmes, or their equivalents in ministries of health, and for other policy-makers working on TB and HIV and infectious diseases. They are also appropriate for officials in other line ministries with work in the areas of health.
World Health Organization
The guidelines fill a gap in providing tools for surveying HIV prevalence in key populations, and the included questionnaires may also inform general population surveys.
World Health Organization
Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: second edition June 2016
World Health Organization
Guidelines
World Health Organization
WHO policy brief
World Health Organization
This policy brief provides an overview of the WHO Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy.
World Health Organization
Guidelines
World Health Organization
WHO recommends assistance for people with HIV to notify their partners
World Health Organization
WHO recommends HIV self-testing
World Health Organization
Supplement to consolidated guidelines on HIV testing services
In this new consolidated guidelines document the World Health Organization brings together all existing guidance relevant to five key populations – men who have sex with men, people who inject drugs, people in prisons and other closed settings, sex workers and transgender people – and updates selected guidance and recommendations.
These WHO guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, treatment and care.
These guidelines aim to reduce morbidity and mortality related to TB and HIV-associated TB among people who inject drugs (PWID) through the integrated delivery of a comprehensive and holistic package of care.
This report from UNAIDS and the WHO discusses the six elements of HIV prevention efforts that are crucial to achieve the target of reducing HIV incidence to 500 000 or fewer by 2020. commitment, focus, synergies, innovation, coverage and accountability
WHO's Sept 2015 guidelines
Update to 2007 guidance to include all types of migrants and crisis-affected populations,
including those forcibly displaced. This update stresses that migration and forced displacement
must NO T be used as an excuse to deny treatment. Clear recommendations are provided for states,
clinicians and programme managers, civil society, donors and United Nations (UN ) agencies.
The WHO has released its first ever set of guidelines for the prevention, care and treatment of persons with chronic hepatitis B (HBV) infection on 12 Mar 2015, following the publication of its guidelines on managing HCV in 2014.
The updated WHO Guidelines on post-exposure prophylaxis for HIV for adults, adolescents and children were launched in January 2015
The WHO Department of Maternal, Newborn, Child and Adolescent Health (MCA), in collaboration with the Department of HIV/AIDS, has developed these guidelines on the treatment of common
skin and oral conditions associated with HIV.
World Health Organization
The WHO has developed guidance for HCWs on how to support children up to 12 years of age and their caregivers with disclosure of HIV status.
